Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body
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منابع مشابه
Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body
The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the following groups: control, dexamethasone (7 mg/week), dexamethasone (0.7 mg/week), methylprednisolone (7 mg/kg/week), methylprednisolone (5 mg/kg twice weekly), dexamethasone (7 mg/kg three ti...
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conclusions in contrast to the findings in humans and certain other species, glucocorticoid administration caused anabolic effect on the cortical bone of tibia diaphysis bone in rats. results glucocorticoid-treated rats showed weight loss and considerable mortality (21%). the biomechanical properties (maximum force) of glucocorticoid-treated rats in groups 4 (62 ± 2.9), 6 (63 ± 5.1), and 7 (60 ...
متن کاملEvaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
BACKGROUND Osteoporosis is a disease, which causes bone loss and fractures. Although glucocorticoids effectively suppress inflammation, their chronic use is accompanied by bone loss with a tendency toward secondary osteoporosis. OBJECTIVES This study took into consideration the importance of cortical bone in the entire bone's mechanical competence. Hence, the aim of this study was to assess t...
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Linkage of vertebral bone marrow fat content with biomechanical strength and trabecular bone structure parameters Thomas Baum, Stefan Ruschke, Olga Gordijenko, Eduardo Grande Garcia, Hendrik Kooijman, Rainer Burgkart, Ernst J Rummeny, Jan S Bauer, and Dimitrios C Karampinos Department of Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Bavaria, Germany, Philips Healt...
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Objective(s) This study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats. Materials and Methods Twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. After 2 weeks, serum total c...
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ژورنال
عنوان ژورنال: Laboratory Animal Research
سال: 2015
ISSN: 1738-6055,2233-7660
DOI: 10.5625/lar.2015.31.4.180